Targeting ROCK2 for Atopic Dermatitis Relief
Abstract
Atopic dermatitis (AD) remains a significant therapeutic challenge. This Viewpoint summarizes the discovery of compound 10d, a natural product-inspired selective ROCK2 inhibitor, whose design was guided by the identification of a novel hydrophobic surface unique to ROCK2. The compound demonstrates compelling efficacy in a mouse model of MC903-induced AD, positioning selective ROCK2 inhibition as a promising strategy for this condition.
Fields of Study & Subjects
Dermatology and Skin Diseases
Protein Kinase Regulation and GTPase Signaling
Computational Drug Discovery Methods
Publication details
- Journal / source
- Journal of Medicinal Chemistry
- Volume
- 69
- Issue
- 5
- Pages
- 5169–5171
- Publication date
- 27 February 2026
- Language
- EN