Design and Synthesis of Bis-Triazole-Linked Benzenesulfonamides as Selective Carbonic Anhydrase IX/XII Inhibitors with Chemosensitizing Activity

Journal of Medicinal Chemistry 2026 Open access

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Authors: Eslam Roshdy, Ahmet Kilic, Muhamad Mustafa, Ismail Celik, Zeynep Betül Sarı, Ender Şi̇mşek, Alessio Nocentini, Simone Giovannuzzi, Claudiu T Supuran, Özen Özensoy Güler, Jean‐Yves Winum, Manabu Abe
DOI: 10.1021/acs.jmedchem.6c00547
Cited by: 1
References: 40

Abstract

significantly enhanced the antiproliferative effects of azacitidine and sorafenib in breast and pancreatic cancer cells under both normoxic and hypoxic conditions. Molecular modeling and simulation studies further supported productive zinc coordination and stable active-site interactions. Overall, these findings highlight bis-triazole benzenesulfonamides as promising scaffolds for targeting hCA IX/XII-expressing tumors and improving chemosensitivity to conventional chemotherapeutics to overcome cancer resistance.

Fields of Study & Subjects

Enzyme function and inhibition Synthesis and Catalytic Reactions Cancer Hypoxia and Metabolism

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
9
Pages
11365–11381
Publication date
30 April 2026
Language
EN