Structure-Based Design and Optimization of Novel, Potent and Selective Covalent FGFR2/3 Inhibitors with a Tricyclic Core

Journal of Medicinal Chemistry 2026

View at publisher
Authors: Xuzhi Lu, Zhaodi Tian, X.C. Li, Xiaojuan Chen, Jean Ching-Yi Tien, Yayuan Yang, Yue Yin, Qi Li, weixue huang, Fengtao Zhou, Junhua Zhang, Xiaomei Ren
+8 more D L Liu, Abigail J. Todd, Shuqin Li, Yuehua Chen, Arul M. Chinnaiyan, Shaohua Chang, Ke Ding, Zhen Wang
DOI: 10.1021/acs.jmedchem.6c00585
Cited by: 1
References: 37

Abstract

demonstrated favorable oral bioavailability (56%) in rats and achieved significant tumor growth inhibition in an SNU-16 gastric cancer xenograft model.

Fields of Study & Subjects

Fibroblast Growth Factor Research Fluorine in Organic Chemistry Multicomponent Synthesis of Heterocycles

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
12
Pages
14627–14646
Publication date
8 June 2026
Language
EN