Don’t Lose Your (War)head: Structure–Activity Relationships of Covalent Warheads as Substrates for GST-Catalyzed Glutathione Conjugation
Abstract
values correlate closely with compound half-lives in human liver cytosol. Together, these findings establish GST susceptibility as a structurally tunable determinant of metabolic GSH conjugation and provide new principles for the optimization of TCIs.
Fields of Study & Subjects
Sulfur Compounds in Biology
Glutathione Transferases and Polymorphisms
Redox biology and oxidative stress
Publication details
- Journal / source
- Journal of Medicinal Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 69
- Issue
- 9
- Pages
- 11574–11591
- Publication date
- 30 April 2026
- Language
- EN