A Near-Infrared Photoactivatable, Brain-Penetrant Prodrug of the Prolyl Hydroxylase Inhibitor Vadadustat for Neuroprotection in Ischemic Stroke

Journal of Medicinal Chemistry 2026

View at publisher
Authors: Ke Li, Tiande Bing, Yikai Mo, Wenxuan Wang, Jihong Xing, Le Yang, Danni Ao, Zhihong Li, Fulai Yang, Yue Wu, Xiaojin Zhang
DOI: 10.1021/acs.jmedchem.6c01014
Cited by: 1
References: 36

Abstract

reduced infarct volume and brain edema, and promoted neurological recovery. These findings highlight a photoactivatable, brain-penetrant prodrug strategy for spatiotemporally controlled neuroprotection.

Fields of Study & Subjects

Neurological Disorders and Treatments Neurological Disease Mechanisms and Treatments Acute Ischemic Stroke Management

Publication details

Journal / source
Journal of Medicinal Chemistry
Publisher
American Chemical Society (ACS)
Volume
69
Issue
10
Pages
12702–12721
Publication date
2 May 2026
Language
EN