Salinirifamycins A–E: Rifamycin S Derivatives from the Brazilian Marine Actinomycete Salinispora arenicola

Journal of Natural Products 2026 Open access

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Authors: Alison Batista da Silva, Francisco Chagas Lima Pinto, E. R. Silveira, Tercio de Freitas Paulo, Diego Veras Wilke, Elthon G. Ferreira, Leticia V. Costa-Lotufo, Kirley Marques Canuto, José Delano Barreto Marinho Filho, Ayslan B. Barros, Genoveffa Nuzzo, Angelo Fontana
+2 more Norberto Kássio. V. Monteiro, Otilia D. L. Pessoa
DOI: 10.1021/acs.jnatprod.5c01381
Cited by: 2
References: 28

Abstract

High Resolution Image Download MS PowerPoint Slide Five new rifamycin derivatives, named salinirifamycins A–E ( 1 – 5 ), were isolated from a Brazilian marine Salinispora arenicol a (BRA-213) strain extract. The structures of the new rifamycins were elucidated using a combination of NMR, IR, UV, and MS spectroscopic techniques, quantum-chemical calculations (DFT-calculated 13 C NMR chemical shifts and DP4+ probability analysis), and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1, 2, and 4 displayed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with MIC values ranging from 2.0 to 125.0 μg/mL, whereas 5 exhibited an MIC of 0.02 μg/mL to S. aureus, similar to the positive control rifampicin (MIC 0.03 μg/mL).

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Carbohydrate Chemistry and Synthesis Synthesis and Biological Activity

Publication details

Journal / source
Journal of Natural Products
Publisher
American Chemical Society (ACS)
Volume
89
Issue
1
Pages
304–312
Publication date
1 January 2026
Language
EN