Gonystylones A–E, Antiproliferative 5,6-Dihydro-α-pyrones from the Plant Gonystylus borneensis

Journal of Natural Products 2026 Open access

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Authors: Chang‐Kwon Kim, Vítor F. Freire, Soumili Dey, Girma Moges Woldemichael, Yong Yean Kim, Xinyu Wen, Hsien-Chao Chou, Young K. Song, Jun Stephen Wei, Rhone K. Akee, Maria Orfanoudaki, Masoumeh Dalilian
+3 more Javed Mohammed Khan, Tanja Grkovic, Barry R. O’Keefe
DOI: 10.1021/acs.jnatprod.5c01620
Cited by: 0
References: 33

Abstract

High Resolution Image Download MS PowerPoint Slide A high-throughput screening campaign designed to discover natural product inhibitors of rhabdomyosarcoma oncogene PAX3–FOXO1 gene expression identified partially purified fractions from an organic extract of the plant Gonystylus borneensis to have potent activity in the assay. Bioassay-guided isolation yielded five new 5,6-dihydro-α-pyrone natural products, namely, gonystylones A–E ( 1–5 ). Their structures were elucidated using 1D and 2D NMR experiments and their absolute configurations determined using semisynthetic and electronic circular dichroism methods. The gonystylones were found to be cytotoxic to rhabdomyosarcoma cells at low micromolar concentrations (3–19 μM).

Fields of Study & Subjects

Bioactive natural compounds Sesquiterpenes and Asteraceae Studies Natural Compound Pharmacology Studies

Publication details

Journal / source
Journal of Natural Products
Volume
89
Issue
2
Pages
762–769
Publication date
18 February 2026
Language
EN