Structure Revision, Absolute Configuration Determination, and Biological Evaluation of Furanonaphthoquinone I

Journal of Natural Products 2026

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Authors: Di Mao, Xinhang Su, Chao Liu, Baoyue Wei, Yichen Yang, Xiaodong Li, Cuili Chen, Yanmin Zou, Zhengyi Ling, Hideaki Kakeya, Lingling Ding, Shan Lu
DOI: 10.1021/acs.jnatprod.6c00007
Cited by: 1
References: 33

Abstract

Structure revision represents a cornerstone and an integral component of natural product chemistry. In this study, the planar structure of furanonaphthoquinone I (FNQI, 1 ) was revised, and its absolute configuration was determined through chemical derivatization, analysis of X-ray crystallography, and electronic circular dichroism (ECD) calculations. The revision of the chemical structure of 1 to 1a led to a corresponding reassessment of its biosynthetic pathway. Biological investigation revealed that 1a exhibited noncytotoxicity against human cancer cells and antibacterial activity against Gram-positive bacteria in vitro and in vivo .

Fields of Study & Subjects

Bioactive Compounds and Antitumor Agents Morinda citrifolia extract uses Molecular spectroscopy and chirality

Publication details

Journal / source
Journal of Natural Products
Publisher
American Chemical Society (ACS)
Volume
89
Issue
3
Pages
992–999
Publication date
27 February 2026
Language
EN