Lyngbyabellin Q, an Antimalarial Cyclic Peptide, and Its Acyclic Analog from a Cyanobacterial Biomat Dominated by Moorena sp.

Journal of Natural Products 2026

View at publisher
Authors: Ryo Koyama, Nao Tanaka, Aki Ishiyama, Aoi Kimishima, Natsumi Watanabe, Shunta Hara, Yukihiro Asami, Arihiro Iwasaki
DOI: 10.1021/acs.jnatprod.6c00068
Cited by: 0
References: 22

Abstract

Abstract Two new lyngbyabellin analogs, Q (1) and R (2), were isolated from a marine cyanobacterial biomat dominated by Moorena sp. Their structures were established primarily through a combination of spectroscopic analyses and degradation reactions. Lyngbyabellin Q (1) inhibited the growth of HeLa cells and disrupted actin dynamics. In addition, lyngbyabellin Q (1) exhibited potent antimalarial activity with an IC50 value of 22 nM, and a new structure–activity relationship enhancing selectivity for the growth inhibition of Plasmodium falciparum over mammalian cells was identified.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Marine Sponges and Natural Products Chemical Synthesis and Analysis

Publication details

Journal / source
Journal of Natural Products
Volume
89
Issue
3
Pages
1038–1044
Publication date
2 March 2026
Language
EN