Chalcone-Terpene Hybrids from Fissistigma litseifolium (King) Merr as Potential Carbapenemase Inhibitors

Journal of Natural Products 2026

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Authors: Isabel Ramón Martínez, Cécile Apel, Saoussen Oueslati, Gaëtan Herbette, Jean‐François Gallard, Emily Cioni, Azeana Zahari, Thierry Naas, Sandy Desrat, Fanny Roussi
DOI: 10.1021/acs.jnatprod.6c00338
Cited by: 1
References: 39

Abstract

species. Phytochemical investigation resulted in the isolation of nine compounds, including three unreported natural products. Of these, fissisteifolin, a quinone, features a unique tetracyclic structure deriving from a chalcone and an uncommon monoterpene. Finally, fissistidin, an original chalcone-sesquiterpene dimer, exhibited 83% reduction in KPC-2 enzyme activity, establishing its potential as a candidate for developing novel carbapenemase inhibitors.

Fields of Study & Subjects

Traditional and Medicinal Uses of Annonaceae Phytochemical compounds biological activities Plant-derived Lignans Synthesis and Bioactivity

Publication details

Journal / source
Journal of Natural Products
Publisher
American Chemical Society (ACS)
Volume
89
Issue
6
Pages
1883–1892
Publication date
30 May 2026
Language
EN