5-Iodo-2-methylthio-6-methyl(trifluoromethyl)pyrimidin-4(3 H )-ones vs Their 4-Methoxylated Derivatives in Suzuki-Miyaura Cross-Coupling Reaction for the Synthesis of Bioactive 5-Arylpyrimidines

The Journal of Organic Chemistry 2026

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Authors: Oleg E. Melnikov, Natalia А. Elkina, Evgeny V. Shchegolkov, Yanina V. Burgart, Рудомётова Надежда Борисовна, Л. И. Карпенко, Н. А. Герасимова, Natalia P. Evstigneeva, Alexander S. Filimonov, O. V. Soldatova, Anna Shitova, М. В. Филимонова
+1 more Victor I. Saloutin
DOI: 10.1021/acs.joc.5c02028
Cited by: 0
References: 72

Abstract

Abstract The reactivities were compared for 5-iodo-2-methylthio-6-methyl(trifluoromethyl)pyrimidin-4(3H)-ones and their 4-methoxylated derivatives in the Suzuki-Miyaura cross-coupling reactions. The iodopyrimidinones were shown to be poorly involved in these reactions, since the target 5-arylpyrimidinones (5 examples) were obtained in low yield (

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Synthesis of heterocyclic compounds

Publication details

Journal / source
The Journal of Organic Chemistry
Volume
91
Issue
18
Pages
6169–6180
Publication date
26 February 2026
Language
EN