Photoexcited Nitroarene-Mediated Oxidation Enables the Total Synthesis of (−)-Securingine G

The Journal of Organic Chemistry 2026

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Authors: Valeriia Zvereva, Sunkyu Han
DOI: 10.1021/acs.joc.5c02257
Cited by: 3
References: 38

Abstract

In general, dehydrogenation of piperideine and piperidine to pyridine requires precious transition-metal catalysts or harsh oxidative conditions. In this study, we show that photoexcited triplet-state nitroarenes act as effective dehydrogenation agents for a one-step anaerobic aromatization of these cyclic amines. The utility of this transformation is demonstrated in the second-generation total synthesis of securingine G.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Phenothiazines and Benzothiazines Synthesis and Activities Synthesis and pharmacology of benzodiazepine derivatives

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
2
Pages
1240–1243
Publication date
2 January 2026
Language
EN