One-Pot Synthesis and Photochemical Diversification of Pyrazolo[1,2- a ]pyridazinones into 3D-Rich Scaffolds
Abstract
High Resolution Image Download MS PowerPoint Slide We report a one-pot, three-component synthesis of pyrazolo[1,2- a ]pyridazinones from tetrahydropyridazines, a transformation that was historically challenging due to competing ring contractions. The resulting compounds undergo photoinduced transformations, without the need for external photocatalysts, to afford diverse 3D-rich derivatives, including tricyclic cyclobutenes and γ-(pyrazol-1-yl)butanals. Enabled by mild conditions, this strategy offers an efficient, atom-economical route to structurally diverse pyrazolo[1,2- a ]pyridazinones and their derivatives.
Fields of Study & Subjects
Multicomponent Synthesis of Heterocycles
Synthesis of heterocyclic compounds
Radical Photochemical Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 4
- Pages
- 1563–1570
- Publication date
- 17 January 2026
- Language
- EN