Silver-Catalyzed Enantioselective and Diastereoselective Aldol Reaction of α-Isocyanoacetates with Aldehydes Enabled by Cinchona-Derived Amide Adamantylphosphine Ligands

The Journal of Organic Chemistry 2026

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Authors: Yulong Jiang, Xianghua Zhao, Xinyu Chen, Zhengguo Deng, Dingguo Song, Fei Ling, Weihui Zhong
DOI: 10.1021/acs.joc.5c02366
Cited by: 2
References: 71

Abstract

. Broad substrate scope was demonstrated with both aryl and alkyl aldehydes, and the method enabled atom-economical synthesis of key intermediates for thiamphenicol and chloramphenicol.

Fields of Study & Subjects

Phosphorus compounds and reactions Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
7
Pages
2983–2990
Publication date
7 February 2026
Language
EN