Sequential [3 + 2] Annulation/Intramolecular Transesterification of o -Hydroxyaryl Azomethines and Conjugated Dienes: Access to Chromeno[4,3- b ]pyrrolidines

The Journal of Organic Chemistry 2026

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Authors: Zhenjie Gan, Ganyi Fan, Jiachen Jiang, Yue Wang, Er-Qing Li
DOI: 10.1021/acs.joc.5c02375
Cited by: 2
References: 33

Abstract

Herein, we report a domino cyclization reaction of o -hydroxyaryl azomethines with electron-deficient conjugated dienes. This method provides a novel and efficient pathway for the construction of chromeno[4,3- b ]pyrrolidine derivatives. The protocol exhibits excellent chemoselectivity and a broad substrate scope. Furthermore, the reaction can be scaled up to gram quantities under the standard conditions.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Synthesis of heterocyclic compounds Catalytic Alkyne Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
8
Pages
3064–3073
Publication date
11 February 2026
Language
EN