Fluorohydrin Synthesis via Formal C–H Fluorination of Cyclic Alcohols
Abstract
Installation of C-F bonds, particularly at the expense of C-H bonds, is of exceptional importance in the development of pharmaceuticals, agrochemicals, and advanced materials. Toward introducing this moiety, here we show that cyclic fluorohydrins can be directly generated via formal C-H fluorination of 5-, 6-, 7-, and 8-membered cyclic alcohols using Selectfluor. Mechanistic studies are consistent with fluorohydrin formation via an ionic elimination-hydroxyfluorination cascade proceeding through an alkene intermediate.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 4
- Pages
- 1848–1855
- Publication date
- 13 January 2026
- Language
- EN