Mechanochemical Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC)
Abstract
Over the last 15 years, significant progress has been made in developing mechanochemical approaches for the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, utilizing various starting materials and different copper sources and process parameters. This synopsis systematically discusses developments in the mechanochemical CuAAC reaction, aiming not only to highlight the benefits of employing this approach for designing molecules featuring a 1,2,3-triazole motif but also to provide a comprehensive guide for chemists interested in exploring this area and to stimulate future advances in the field.
Fields of Study & Subjects
Crystallography and molecular interactions
Click Chemistry and Applications
Force Microscopy Techniques and Applications
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 5
- Pages
- 1883–1894
- Publication date
- 22 January 2026
- Language
- EN