Solvent-Free α-Arylation Reaction of Ketones with (Hetero)aryl Chlorides by N -Heterocyclic Carbene–Palladium Complex (SIPr) Ph2 Pd(cin)Cl

The Journal of Organic Chemistry 2026

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Authors: Jia‐Sheng Ouyang, Xiaoling Wang, Huizhen Jiang, Ruiyong Luo, Liqun Hu, Yaqi Zhang, Liqin Qiu
DOI: 10.1021/acs.joc.5c02510
Cited by: 3
References: 61

Abstract

A green and mild palladium-catalyzed solvent-free α-arylation reaction of ketones was disclosed for the first time. Using the robust N -heterocyclic carbene–palladium complex (SIPr) Ph2 Pd(cin)Cl, (hetero)aryl chlorides and ketones were able to generate monoarylation products in excellent yields under solvent-free conditions, with a total of 41 examples. Furthermore, the protocol has been demonstrated to be suitable for multigram-scale preparation with a high yield.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
7
Pages
2701–2707
Publication date
9 February 2026
Language
EN