Iron-Catalyzed Amination of Silyl Enol Ethers Using Hydroxylamine Derivatives

The Journal of Organic Chemistry 2026 Open access

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Authors: G. R. Lee, Georgina Kirby, Sonia Lajnef, Fabienne Peyrot, Laurence Grimaud, Maxime R. Vitale, Guillaume Prestat, Farouk Berhal
DOI: 10.1021/acs.joc.5c02591
Cited by: 2
References: 45

Abstract

An iron-catalyzed intermolecular amination reaction is reported. This transformation proceeds under mild conditions through the combination of silyl enol ethers and hydroxylamine derivatives with a simple iron complex, enabling access to a broad range of α-amino carbonyl products.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Synthesis and Catalytic Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
2
Pages
1101–1113
Publication date
2 January 2026
Language
EN