Synthesis and Functionalization of Thiazolo[ c ]isothiazoles
Abstract
The chalcogen bonding ability of sulfur-containing rings has become a useful development tool in organic chemistry. The explored chemical space of fused thiazoles and isothiazoles is mostly limited to fusions with six-membered rings. Examples of 5,5-fused heteroaromatic scaffolds with multiple sulfur atoms are mostly limited to thiophene rings. This work describes the synthesis and broad functionalizability of building blocks for both thiazolo[5,4- c ]isothiazoles and thiazolo[4,5- c ]isothiazoles, including selective arylation and substitution. Their hydrogen and chalcogen bonding abilities are demonstrated.
Fields of Study & Subjects
Synthesis and Reactivity of Sulfur-Containing Compounds
Crystallography and molecular interactions
Structural and Chemical Analysis of Organic and Inorganic Compounds
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 4
- Pages
- 1666–1669
- Publication date
- 19 January 2026
- Language
- EN