Convergent Synthesis of Highly Functionalized Furans

The Journal of Organic Chemistry 2026

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Authors: Jacky Lim, Julia B. DiSapio, Stewart K. Richardson, Amy R. Howell
DOI: 10.1021/acs.joc.5c02670
Cited by: 0
References: 31

Abstract

A one-pot preparation of highly functionalized furans from two readily accessible starting materials, 2-methyleneoxetanes (or 2-alkylideneoxetanes) and α-diazoketones, is reported. The mild, convergent process takes advantage of transition-metal-mediated cyclopropanation/rearrangement (CP/RA), followed by elimination, to give controlled furan functionalization.

Fields of Study & Subjects

Cyclopropane Reaction Mechanisms Organic Chemistry Synthesis Methods Catalytic Alkyne Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Volume
91
Issue
7
Pages
3007–3011
Publication date
10 February 2026
Language
EN