Copper(I)-Catalyzed Interrupted CuAIAC/Disulfuration Reaction for the Synthesis of N,N ′-Bicyclic Pyrazolidinone Disulfides

The Journal of Organic Chemistry 2026

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Authors: Weiguo Wang, Jingyu Wang, Yanqin Wang, Yanqin Wang, Chunpeng Qiu, Fanjun Zhang, Younan Wang, Younan Wang
DOI: 10.1021/acs.joc.5c02696
Cited by: 2
References: 48

Abstract

'-bicyclic pyrazolidinone disulfides were prepared via a copper(I)-catalyzed interrupted CuAIAC/disulfuration cascade reaction. This protocol proceeded through a copper(I)-catalyzed azomethine imine-alkyne cycloaddition, followed by the interception of the in situ-formed cuprate-pyrazolidinonate intermediate with trisulfide dioxides. The reaction exhibits complete regioselectivity, mild conditions, and broad functional group compatibility, including halogen, cyano, and heterocycle, making it a highly efficient synthetic strategy.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods Chemical Synthesis and Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
5
Pages
2284–2288
Publication date
22 January 2026
Language
EN