TBAF Controlled Access to 1,4,5-Trisubstituted and 1,5-Disubstituted Pyrido-triazoles from Tetrazolopyridine with β-Keto Ester and Their Anti-leishmanial Efficacy Studies
Abstract
The synthesis of 1,4,5-trisubstituted pyrido-triazole and 1,5-disubstituted pyrido-triazole, from tetrazolopyridine and 1,3-dicarbonyl compounds using tetrabutyl ammonium fluoride (TBAF) salt, is reported here. The concentration of TBAF in the reaction medium dictates the selectivity of formation of two pyrido-triazoles. The gram-scale synthesis and late-stage modification of the ester substituent further enhance the synthetic utility of this methodology. Anti-leishmanial screening of selected 15 trisubstituted pyrido-triazoles revealed moderate activity against promastigotes and axenic amastigotes.
Fields of Study & Subjects
Synthesis and Characterization of Heterocyclic Compounds
Synthesis of Tetrazole Derivatives
Structural and Chemical Analysis of Organic and Inorganic Compounds
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 4
- Pages
- 1686–1693
- Publication date
- 13 January 2026
- Language
- EN