Synthesis of Selaginpulvilin D by [2 + 2 + 2] Cyclotrimerization─A Second-Generation Approach
Abstract
We report a second-generation synthesis of selaginpulvilin D that addresses key limitations of our earlier route. An efficient early-stage [2 + 2 + 2] cyclotrimerization now provides high-yield access to the molecule's fluorene core. Previously, this step was low-yielding and relied on a difficult-to-prepare aryldiyne intermediate. By introducing the arylalkyne moiety after the cyclotrimerization, the new strategy removes these issues and delivers a more practical, efficient, and modular pathway to selaginpulvilin D.
Fields of Study & Subjects
Cyclization and Aryne Chemistry
Organic Chemistry Synthesis Methods
Catalytic Alkyne Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 4
- Pages
- 1860–1863
- Publication date
- 14 January 2026
- Language
- EN