Visible-Light-Induced Acridinium and Pyridine N -Oxide Dual Catalysis for Direct Acylation of Azauracils with Aldehydes
Abstract
A visible-light-driven cross-dehydrogenative coupling of azauracils with aldehydes is described by using dual acridinium photoredox and pyridine N -oxide hydrogen atom transfer catalysis. This oxidant-free method generates acyl radicals under mild conditions, tolerates diverse functional groups, proceeds under air, and is scalable to gram quantities. Mechanistic studies support the selective oxidation of pyridine N -oxide by the photoexcited catalyst, enabling aldehyde activation. This operationally simple protocol provides a sustainable platform for the late-stage functionalization of nitrogen-rich heterocycles.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 5
- Pages
- 2113–2120
- Publication date
- 26 January 2026
- Language
- EN