Dimeric Furanones with a Unique Polycyclic Spiro Skeleton from Hawk Tea
Abstract
Six novel furanone derivatives, hawktealide A–F ( 1 – 6 ), featuring a novel 5/6/5 tricyclic system containing with a spiro-ring, were isolated from hawk tea. The structures of these compounds were confirmed using high-resolution electrospray ionization mass spectrometry (HR-ESIMS), nuclear magnetic resonance (NMR), electronic circular dichroism (ECD), and single-crystal X-ray diffraction data. Compounds 1 – 3 showed concentration-dependent cytotoxicity against AsPC-1 and HCT-116 cells. Compound 1 was notably more potent against AsPC-1 cells than against HCT-116 or L02 cells. Further experiments revealed that compound 1 induced autophagy, inhibited migration, and caused cell cycle arrest in AsPC-1 cells.
Fields of Study & Subjects
Tea Polyphenols and Effects
Plant chemical constituents analysis
Sesquiterpenes and Asteraceae Studies
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 8
- Pages
- 3109–3117
- Publication date
- 12 February 2026
- Language
- EN