Enantioselective Hydrolactonization Catalyzed by Chiral Borophosphates
Abstract
The direct asymmetric hydrolactonization of olefinic carboxylic acids without the aid of electrophilic initiators remains a significant challenge in synthetic chemistry. Herein, we report an enantioselective, metal-free hydrolactonization of olefinic carboxylic acids utilizing an in situ -generated chiral borophosphate as the catalyst. A variety of optically active lactones were obtained in excellent yields with good to high enantioselectivities. This protocol provides a facile and efficient approach to the construction of lactones bearing methyl-substituted tertiary stereocenters.
Fields of Study & Subjects
Organoboron and organosilicon chemistry
Asymmetric Hydrogenation and Catalysis
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 4
- Pages
- 1864–1868
- Publication date
- 15 January 2026
- Language
- EN