Visible-Light-Driven Copper Catalysis: A Green and Sustainable Approach to Chlorohydroxylation of Chalcones

The Journal of Organic Chemistry 2026

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Authors: Qi Shi, Dong-Xiang Li, Xing-Lan Wang, Yu-Rong Yang, Xin-Yu Zhang, Cheng‐He Zhou, Zhong‐Lin Zang, Gui-Xin Cai
DOI: 10.1021/acs.joc.5c02788
Cited by: 2
References: 55

Abstract

This work reports a green and sustainable method of chlorohydroxylation of chalcone derivatives via visible-light-induced copper catalysis under room temperature conditions to chemoselectively convert chalcones into the corresponding chlorohydrins. This approach enables the efficient conversion of various chalcone derivatives with electron-withdrawing and electron-donating groups. Preliminary mechanistic studies indicated that chlorine radical (Cl · ) generated through the ligand-to-metal charge transfer process can promote the efficient construction of chlorohydrin structures.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Synthesis and Biological Evaluation

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
6
Pages
2468–2474
Publication date
30 January 2026
Language
EN