Cobalt-Catalyzed Asymmetric Reductive Propargylic Addition of α-Ketimino Esters
Abstract
The Nozaki-Hiyama-Kishi (NHK) reaction serves as a powerful method for stereoselective carbon-carbon bond formation under mild conditions. While significant progress has been made in the enantioselective propargylation of carbonyl compounds, its application to imines remains underdeveloped. Herein, we report a catalytic asymmetric reductive propargylic addition to α-ketimino esters, providing direct access to chiral propargylated amines with high chemoselectivity and enantioselectivity. This method expands the synthetic utility of NHK-type reactions toward nitrogen-containing scaffolds, offering a complementary route to enantioenriched amine derivatives under mild and efficient conditions.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Asymmetric Hydrogenation and Catalysis
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 7
- Pages
- 2791–2797
- Publication date
- 6 February 2026
- Language
- EN