Photoredox/Copper Dual-Catalyzed Remote C(sp 3 )-H Acyloxylation of N -Fluorocarboxamides

The Journal of Organic Chemistry 2026

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Authors: Xuesong Wang, Fuqi Li, Xueli Liu, Haohai Li, Qiongjiao Yan, Wei Wang
DOI: 10.1021/acs.joc.5c02799
Cited by: 0
References: 65

Abstract

We herein disclose the first example of a photoredox/copper dual-catalyzed protocol for the remote C(sp 3 )-H acyloxylation of N -fluorocarboxamides, employing readily accessible carboxylic acids as acyloxy sources. This methodology demonstrated tolerance for various N -fluoroamides and carboxylic acids, producing structurally diverse functional esters in moderate-to-excellent yields with high site selectivity and chemoselectivity. Moreover, the developed methodology was successfully employed for the late-stage modification of structurally intricate natural products and drugs.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Fluorine in Organic Chemistry Radical Photochemical Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Volume
91
Issue
3
Pages
1431–1443
Publication date
8 January 2026
Language
EN