Fluxional Axially Chiral P,Pyridine Ligands for Pd-Catalyzed Asymmetric Allylic Alkylation

The Journal of Organic Chemistry 2026

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Authors: Kohei Watanabe, Ayano Suzuki, Nana Oguri, Yasushi Yoshida, Yoshio Kasashima, Ryo Takita, Masami Sakamoto, Takashi Mino
DOI: 10.1021/acs.joc.5c02806
Cited by: 1
References: 34

Abstract

with fluxional chirality and demonstrated Pd-catalyzed asymmetric allylic alkylation with malonates achieving high enantioselectivities (up to 91% ee). DFT calculations suggest that the chiral phenylethyl moiety plays a crucial role in attaining enantioselectivity by regulating not only the fluxional axial chirality of the ligand but also the orientation of the π-allyl group through CH-π interactions.

Fields of Study & Subjects

Axial and Atropisomeric Chirality Synthesis Asymmetric Synthesis and Catalysis Synthesis and Properties of Aromatic Compounds

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
2
Pages
1156–1164
Publication date
5 January 2026
Language
EN