Copper Powder-Catalyzed α-Alkynylation of Secondary Alcohols via Isodesmic Reaction

The Journal of Organic Chemistry 2026

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Authors: Min Lin, Zixin Ye, Fei-Fei Zou, Cheng Liang, Si-Qi Xiong, Qing-Hua Li, Tang‐Lin Liu
DOI: 10.1021/acs.joc.5c02835
Cited by: 1
References: 51

Abstract

Copper powder-catalyzed α-alkynylation of secondary alcohols via an isodesmic reaction was established. The synergistic interaction between copper powder and 1,10-phenanthroline was identified as the pivotal factor in significantly boosting the activity of the reaction. This α-alkynylation of secondary alcohols provides a step-economic procedure for preparing CF 3 -substituted propargylic alcohols. This reaction proceeds under open-air conditions, exhibiting a broad substrate scope and excellent compatibility with the late-stage modification of bioactive molecules.

Fields of Study & Subjects

Catalytic Alkyne Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
7
Pages
2817–2825
Publication date
10 February 2026
Language
EN