Phosphinylalkylation of Indoles and Anilines Enabled by Electron-Donor–Acceptor (EDA) Complex Photoexcitation
Abstract
Visible light-mediated, multicomponent, regioselective phosphinylalkylation of indoles with readily available carbonyl compounds and diaryl phosphine oxides at ambient temperature is demonstrated. The strategy presented here is also effective with anilines. Key to this transformation is the electron-donor-acceptor (EDA) complex formation between the in situ generated (vinylogous) iminium intermediate and secondary phosphine oxides. Mechanistic studies supported the EDA complex-enabled radical pathway.
Fields of Study & Subjects
Radical Photochemical Reactions
Organophosphorus compounds synthesis
Phosphorus compounds and reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 11
- Pages
- 4009–4020
- Publication date
- 6 March 2026
- Language
- EN