TfOH/HFIP Cluster-Promoted Direct C–F Bond Activation of Trifluoromethyl Arenes/Alkanes
Abstract
A direct C-F bond activation for trifluoromethyl compounds promoted by the TfOH/HFIP cluster is developed, allowing the conversion of various trifluoromethyl arenes and trifluoromethylalkanes to diverse carboxylic acids and their derivatives. This method is distinguished by its broad substrate scope, good functional group tolerance, and exclusive regioselectivity. The utility of this reaction is further showcased on a gram scale and in the synthesis of the ultraviolet (UV) absorber and fenofibrate. Control experiments confirmed the crucial role of the TfOH/HFIP cluster in achieving this efficient conversion.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Inorganic Fluorides and Related Compounds
Radical Photochemical Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 4
- Pages
- 1737–1744
- Publication date
- 14 January 2026
- Language
- EN