Clathriamine A, an Antibacterial Dimeric Araiosamine Homologue from a Marine Sponge Clathria (Thalysias) sp.

The Journal of Organic Chemistry 2026

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Authors: Samuele Sala, Brodie W. Bulcock, Gareth L. Nealon, Jane Fromont, Oliver Gomez, Daniel Vuong, Ernest Lacey, Gavin R. Flematti
DOI: 10.1021/acs.joc.5c02852
Cited by: 0
References: 37

Abstract

A novel bis-indole, bis-guanidinium alkaloid, clathriamine A ( 1 ), has been isolated from a Western Australian marine sponge, Clathria (Thalysias) sp. (order: Poecilosclerida, family: Microcionidae). The structure of 1 was elucidated via comprehensive NMR analyses as well as TD-DFT predictions of ECD spectra. Biological evaluation against a panel of microorganisms and cell lines revealed potent and selective antibacterial activity for compound 1 .

Fields of Study & Subjects

Marine Sponges and Natural Products Synthesis and Biological Activity Microbial Natural Products and Biosynthesis

Publication details

Journal / source
The Journal of Organic Chemistry
Volume
91
Issue
8
Pages
3180–3187
Publication date
18 February 2026
Language
EN