Photocatalytic Hydroxyalkylation of Heteroarenes with Aldehydes
Abstract
The photoredox hydroxyalkylation of heteroaromatics with aldehydes proceeds under mild and neutral conditions. This transition-metal- and oxidant-free hydroxyalkylation proceeds efficiently with various heteroarenes and aldehydes and has been applied to the late-stage modification of pharmaceutically active molecules, and on a gram-scale. (PhO) 2 PO 2 H plays multiple roles in this transformation, including protonation, hydrogen atom transfer (HAT) and electron transfer.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 3
- Pages
- 1444–1453
- Publication date
- 8 January 2026
- Language
- EN