Synthesis of 2-Thioxo-1,3-benzothiazin-4-one by PPh 3 -Promoted Desulfurative [4 + 2] Annulation

The Journal of Organic Chemistry 2026

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Authors: Chuan‐Chuan Wang, MENG-RU REN, Q. H. Wang, Shu-Yan Wu, Hong Zhang, Zhi‐Hao Wang, Yao-Jie Xue, Yajing Chen
DOI: 10.1021/acs.joc.5c02876
Cited by: 3
References: 34

Abstract

An efficient construction of 2-thioxo-1,3-benzothiazin-4-ones has been developed via a PPh 3 -promoted desulfurative [4 + 2] annulation between benzo[ c ][1,2]dithiol-3-ones and isothiocyanates. This strategy is characterized by its mild reaction conditions, operational simplicity, excellent yields, wide functional group tolerance, accessible scalability, and practical transformations.

Fields of Study & Subjects

Quinazolinone synthesis and applications Sulfur-Based Synthesis Techniques Phenothiazines and Benzothiazines Synthesis and Activities

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
4
Pages
1753–1757
Publication date
14 January 2026
Language
EN