Photocatalytic Silylation/Germylation and Cascade Cyclization of N -( o -Cyanobiaryl)acrylamides: Access to Silylated and Germylated Phenanthridines
Abstract
We report a highly efficient protocol for the synthesis of silylated/germylated phenanthridine derivatives through the photocatalytic radical cascade cyclization of N -aryl acrylamides. A simple N -aminopyridinium salt was used as a hydrogen atom transfer reagent to generate a silyl/germyl radical under photoredox catalytic conditions. This method demonstrates a broad substrate scope and is suitable for the late-stage functionalization of natural products and pharmaceuticals with a shorter reaction time. Moreover, photophysical studies of selected phenanthridine derivatives highlight the promising luminescence properties with excellent fluorescence emission efficacy (quantum yields).
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 6
- Pages
- 2515–2522
- Publication date
- 31 January 2026
- Language
- EN