Photoinduced Tandem Cyclization of Unsaturated Hydrazones with CF 3 CH 2 I to Access Trifluoroethylated Tetrahydropyridazines and Dihydropyrazoles
Abstract
A visible-light-mediated trifluoroethylation/cyclization reaction of N -homoallyl aldehyde hydrazones with 1,1,1-trifluoro-2-iodoethane (CF 3 CH 2 I) was developed for the synthesis of trifluoroethylated tetrahydropyridazines. The reaction was conducted under mild conditions with good functional group compatibility. Moreover, the synthesis of trifluoroethylated dihydropyrazoles was also achieved via the trifluoroethylation/cyclization of N -allyl aldehyde hydrazones with CF 3 CH 2 I.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Synthesis and Characterization of Pyrroles
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 5
- Pages
- 2203–2214
- Publication date
- 28 January 2026
- Language
- EN