N -Methylated Peptide Synthesis via In Situ Generation of Pivaloyl Mixed Anhydrides

The Journal of Organic Chemistry 2026

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Authors: Li Liu, Chenchen Qi, Xiangsheng Xu, Xiaoqing Li
DOI: 10.1021/acs.joc.5c02919
Cited by: 3
References: 38

Abstract

-methylated peptide synthesis via in situ generation of pivaloyl mixed anhydrides is developed under mild, base-free conditions. It features high yields, good substrate compatibility, and excellent racemization suppression, outperforming conventional coupling reagents. The method is successfully applied to synthesize cyclosporin A fragments and ciliatamide B.

Fields of Study & Subjects

Chemical Synthesis and Analysis Synthesis and Characterization of Pyrroles Peptidase Inhibition and Analysis

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
16
Pages
5680–5687
Publication date
8 April 2026
Language
EN