Copper-Catalyzed Regio- and Stereo-Defined Protocols to Access β-Aminated Carbonyl Derivatives
Abstract
We report herein a Cu(I)-catalyzed highly regio- and stereoselective vinylic C–H amination reaction to generate ( Z )-enamines, or β-aminated heterocyclic amines and ketones. This strategy involves the Cu I –Cu II –Cu III catalytic cycle-mediated radical addition of in situ -generated N-centered radicals, followed by a stereocontrolled anticoplanar β-H elimination protocol. The β-C–H bond cleavage step is suggested to be involved in the rate-determining step based on the D-labeled kinetic studies.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Synthesis and Catalytic Reactions
Radical Photochemical Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 8
- Pages
- 3208–3217
- Publication date
- 13 February 2026
- Language
- EN