Rh(I)-Catalyzed Dearomative Cycloisomerization of Furan-Tethered o -Alkynylphenyl Nitrones to Tropane-Containing Polycycles

The Journal of Organic Chemistry 2026

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Authors: Xiaowen Ji, Liang Sun, Huiwen Ma, Dandan Shang, Weidong Rao
DOI: 10.1021/acs.joc.5c02929
Cited by: 2
References: 53

Abstract

A synthetic method for the assembly of dihydrofuran-fused tropane-containing polycycles that relies on rhodium(I)-catalyzed 6 - exo - dig cycloaddition/internal redox (IR)/azomethine ylide formation/dearomative [3 + 2] cycloaddition of furan-tethered o -alkynylphenyl nitrones has been developed.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Cyclopropane Reaction Mechanisms

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
6
Pages
2523–2529
Publication date
30 January 2026
Language
EN