Development of a Late-Stage Functionalization Strategy to Access Diverse 3,5-Disubstituted 1,2,4-Thiadiazoles

The Journal of Organic Chemistry 2026 Open access

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Authors: Andrew Dobria, Zoe A. Petros, Philip Mickel, Leslie N. Aldrich
DOI: 10.1021/acs.joc.5c02935
Cited by: 0
References: 25

Abstract

High Resolution Image Download MS PowerPoint Slide Efforts to prepare amine-substituted 1,2,4-thiadiazoles typically incorporate chemical diversity in the early steps of the reaction sequence or through amine choice in coupling and aromatic substitution reactions. We developed a late-stage functionalization approach that enables facile incorporation of complex substituents and diverse nitrogen-containing functional groups at C 3 and C 5 .

Fields of Study & Subjects

Structural and Chemical Analysis of Organic and Inorganic Compounds Synthesis and Reactivity of Sulfur-Containing Compounds Synthesis of heterocyclic compounds

Publication details

Journal / source
The Journal of Organic Chemistry
Volume
91
Issue
8
Pages
3232–3238
Publication date
16 February 2026
Language
EN