Cobalt-Catalyzed C–H Activation/Annulation of N -(Naphthalen-1-yl)amides with Isocyanides: Synthesis of Benzo[ c,d ]indol-2-imines

The Journal of Organic Chemistry 2026

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Authors: Raj N. Patel, Mahesh Sonawane, Dinesh Gopichand Thakur, S. P. Ghosh
DOI: 10.1021/acs.joc.5c02937
Cited by: 1
References: 35

Abstract

This study unveils the first cobalt-catalyzed picolinamide-directed C–H/N–H annulation of N -(naphthalen-1-yl)picolinamide with isocyanides, which efficiently forms benzo[ c,d ]indol-2-imines via peri-C–H activation. Using Ag 2 O and mild conditions, it offers a cost-effective, atom-economical route with a broad substrate scope and in situ directing group removal for simplified synthesis and good yields.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions Synthesis and Catalytic Reactions

Publication details

Journal / source
The Journal of Organic Chemistry
Publisher
American Chemical Society (ACS)
Volume
91
Issue
3
Pages
1454–1461
Publication date
9 January 2026
Language
EN