Pd-Catalyzed Suzuki Coupling Followed by Intramolecular Ipso -Friedel–Crafts Arylation Process: Cascade Synthesis of Hydroxylated Fluorenes
Abstract
A Pd-catalyzed cascade process has been developed for the direct synthesis of hydroxylated fluorenes from o -bromophenyl-substituted p -quinone methides ( p -QMs) and 3-hydroxy-substituted arylboronic acids. This cascade process comprises Suzuki coupling, followed by intramolecular ipso -Friedel–Crafts arylation, which affords the functionalized fluorenes in good yields. This protocol offers several advantages, including substrate versatility and high regioselectivity. Additionally, both symmetrical and unsymmetrical p -quinone methides participate smoothly in this cascade process.
Fields of Study & Subjects
Synthesis of Indole Derivatives
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 12
- Pages
- 4191–4203
- Publication date
- 26 January 2026
- Language
- EN