Copper-Mediated Sulfimidations of Benzylic C(sp 3 )–H Bonds
Abstract
In this study, we describe a strategy for benzylic C(sp 3 )–H activation that enables C–S bond formation through a copper-mediated sulfimidation. Leveraging readily available methylarenes under oxidative conditions, the method provides a complementary route to benzylic sulfilimines directly from simple C(sp 3 )–H precursors. It is applicable to a representative range of sulfenamides and methylarenes, amenable to scale-up, and typically delivers benzylic sulfilimines in moderate yields.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Synthesis and Catalytic Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 13
- Pages
- 4581–4586
- Publication date
- 25 March 2026
- Language
- EN