Synthesis of Indole-Fused Dioxonanes via Brønsted Acid-Catalyzed (5 + 4) Cycloaddition
Abstract
A Brønsted acid-catalyzed (5 + 4) cycloaddition between 3-alkynyl-2-indolylmethanols and o -hydroxybenzyl alcohols was established, which provided an efficient strategy for the synthesis of structurally diverse indole-fused dioxonanes (up to 86% yield). This work provides access to a new class of indole-fused 9-membered rings, simultaneously expanding the scope and utility of organocatalytic (5 + 4) cycloadditions.
Fields of Study & Subjects
Synthesis of Indole Derivatives
Oxidative Organic Chemistry Reactions
Catalytic Alkyne Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 4
- Pages
- 1776–1787
- Publication date
- 15 January 2026
- Language
- EN