Sequential Polychloromethylation/Cyclization of N -Cyanamide Alkenes for the Construction of Polychloromethyl-Containing Quinazolinones
Abstract
A green and efficient radical cascade cyclization method for the synthesis of polychloromethyl-substituted quinazolinones is reported. The polychloromethylation/cyclization process proceeds in 64–93% yields using unactivated alkenes and is characterized by its metal-free conditions, broad substrate scope, and excellent functional group compatibility. This strategy is also applicable to other polyhaloalkanes, offering promising potential for the preparation of pharmaceutically relevant polychloromethyl-substituted N -heterocycles.
Fields of Study & Subjects
Quinazolinone synthesis and applications
Catalytic C–H Functionalization Methods
N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Publisher
- American Chemical Society (ACS)
- Volume
- 91
- Issue
- 6
- Pages
- 2555–2562
- Publication date
- 29 January 2026
- Language
- EN