The Base-Promoted Intermolecular Hydroamination Reaction between Olefins and Indoles
Abstract
Indole, a common nitrogen-containing heterocycle found in numerous FDA-approved drugs, is widely present in diverse bioactive molecules. Conventional methods for N -alkylation of indoles generally require transition-metal catalysts, limiting the substrate scope and operational simplicity. The current research proposed a transition-metal-free, intermolecular hydroamination between indoles and 2-pyridinemethanol-protected 3-butenoic acid derivatives. The reaction proceeds under mild basic conditions with broad substrate compatibility, thus providing a novel and practical approach to the synthesis of N -alkylated indoles.
Fields of Study & Subjects
Synthesis of Indole Derivatives
Catalytic Alkyne Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 4
- Pages
- 1788–1795
- Publication date
- 20 January 2026
- Language
- EN