Iron-Mediated Regioselective C–H Chalcogenation of Tyrosine Derivatives Using Mechanochemistry
Abstract
An iron-mediated direct chalcogenation of tyrosine-containing peptides has been developed. This protocol operates under mechanochemical conditions and exhibits broad functional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated by the late-stage functionalization of pharmaceutical compounds. Preliminary mechanistic studies indicated that a radical pathway is likely to be operative.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- The Journal of Organic Chemistry
- Volume
- 91
- Issue
- 6
- Pages
- 2563–2574
- Publication date
- 3 February 2026
- Language
- EN